Ac-YVAD-CMK

Ac-YVAD-CMK

5 mg
€165,00

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Ac-YVAD-CMK
  • Ac-YVAD-CMK
  • Ac-YVAD-CMK

Ac-YVAD-CMK

Produkt-ID: 3180

Acetyl- L-tyrosyl- L-valyl- L-alanyl- L-aspart-1-yl-Chloromethane

€165,00
exkl. 19% MwSt.
Beschreibung

Ac-YVAD-Chloromethylketone

M.W. 541.00

C24H33N4O8Cl

178603-78-6

Acetyl- L-tyrosyl- L-valyl- L-alanyl- L-aspart-1-yl-Chloromethane

Irreversible Inhibitor for Caspase-1 Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CH2Cl) is used as an irreversible inhibitor for Caspase-1, instead of the pseudo acid (aldehyde) Ac-YVAD-CHO which inhibits caspase reversible. The caspase-1 inhibitor Ac-YVAD-CMK is of interest in reasearch of sepsis and endotoxic shock.

Synthetic Product

Referenzen:

1. Y.A. Lazebnik, S.H. Kaufmann, S. Desnoyers, G.G. Poirier and W.C. Earnshaw, Nature, 371, 346 (1994) 2. M. Enari, H. Hug and S. Nagata, Nature, 375, 78 (1995) 3. C.E. Milligan, D. Prevette, H. Yaginuma, S. Homma, C. Cardwell, L.C. Fritz, K.J. Tomaselli, R.W. Oppenheim and L.W. Schwartz, Neuron, 15, 385 (1995) 4. E. Fujita, T. Mukasa, T. Tsukahara, K. Arahata, S. Omura and T. Momoi, Biochem. Biophys. Res. Commun, 224, 74 (1996)

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