CA-074

CA-074

5 mg
€155,00

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CA-074
  • CA-074
  • CA-074

CA-074

Produkt-ID: 4322

(L- 3- trans- (Propylcarbamoyl)oxirane- 2- Carbonyl) L-isoleucyl- L-proline

€155,00
exkl. 19% MwSt.
Beschreibung

L-trans-Epoxysuccinyl-Ile-Pro-OH propylamide

M.W. 383.44

C18H29N3O6

134448-10-5

(L- 3- trans- (Propylcarbamoyl)oxirane- 2- Carbonyl) L-isoleucyl- L-proline

Inhibitor for Cathepsin BCA-074 (Cathepsin B Inhibitor III) is a selective irreversible inhibitor of cathepsin B with lower membrane permeability as the related methyl ester CA-074 Me. The more specific inhibitor CA-074 enables the inhibition of endogenous cathepsin B, while intracellular cathepsin L remains unaffected. It should be used instead of CA-074 Me for the specific inactivation of cathepsin B in living cells.

Synthetic Product

Referenzen:

1. M. Murata, S. Miyashita, C. Yokoo, M. Tamai, K. Hanada, K. Hatayama, T. Towatari, T. Nikawa and N. Katunuma, FEBS Lett., 280, 307 (1991) (Original; Pharmacol.) 2. T. Towatari, T. Nikawa, M. Murata, C. Yokoo, M. Tamai, K. Hanada and N. Katunuma, FEBS Lett., 280, 311 (1991) (Original; Pharmacology of CA-074) 3. T. Inubushi, H. Kakegawa, Y. Kishino and N. Katsunuma, J. Biochem., 116, 282 (1994) (Biochemisty of CA-074.)

The peptide inhibitor CA-074 is distributed through Peptide Institute, Inc. under the license of Taisho Pharmaceutical Co., Ltd.

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