{"title":"Biologisch aktive Peptide \\ Endothelin-Peptide","description":"\u003cp\u003e\u003cspan\u003eSeit Yanagisawa et al 1998 das erste \u003c\/span\u003e\u003cstrong\u003eEndothelin\u003c\/strong\u003e\u003cspan\u003e als ein potentes Vasokonstriktor-Peptid beschrieben haben, wurden viele weitere Endotheline und Endothelin-verwandte Peptide isoliert und beschrieben. Alle \u003c\/span\u003e\u003cstrong\u003eEndothelin-Peptide\u003c\/strong\u003e\u003cspan\u003e spielen eine wichtige Rolle bei der Regulierung des kardiovaskulären Systems von Säugetieren und sind an verschiedenen Signaltransduktionsprozessen beteiligt. Endothelin-1 (ET-1) und ET-3 werden hauptsächlich aus ihren Vorläuferpeptiden im vaskulären Endothel produziert, während Endothelin-2 (ET-2) in der Niere gefunden wurde. Alle Mitglieder dieser Endothelin-Familie weisen zwei Disulfidbrücken zwischen den Cysteinresten 1-15 und 3-11 auf. Die Entstehung von Endothelin ist ein schrittweiser Prozess. Ein 203-mer Protein namens Präproendothelin wurde in einem ersten Schritt durch eine spezifische Peptidase in das Oligopeptid Big-Endothelin gespalten. Dieses Proendothelin wird durch das Endothelin-konvertierende Enzym in das biologisch aktive Endothelin gespalten. Die Überexpression von Endothelin-Peptiden, insbesondere von ET-1, spielt eine wichtige Rolle bei der Entstehung von Herzkrankheiten. PeptaNova bietet 12 verschiedene Endothelin- und Big-Endothelin-Peptide an, die vom Peptide Institute, Inc. Osaka hergestellt werden. Alle angebotenen Endothelin-Peptide sind synthetischen Ursprungs, hochrein und mit speziellen Assays auf biologische Aktivität getestet. \u003c\/span\u003eSarafatoxin\u003cspan\u003e (B und C), isoliert aus dem Schlangengift von Atractaspis engaddensis, weist viele Ähnlichkeiten mit den Endothelin-Peptiden auf und kann ebenfalls bei PeptaNova bestellt werden.\u0026nbsp;\u003c\/span\u003e\u003c\/p\u003e","products":[{"product_id":"endothelin-1-human","title":"Endothelin-1 (Human)","description":"\u003cp\u003eET-1 (Porcine, Canine, Rat, Mouse, Bovine)\u003c\/p\u003e","brand":"peptanova","offers":[{"title":"0.1MG","offer_id":52785944396118,"sku":"4198-S","price":115.0,"currency_code":"EUR","in_stock":true},{"title":"0.5MG","offer_id":54225692492118,"sku":"4198-V","price":285.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/7940\/1302\/files\/4198.jpg?v=1777022288"},{"product_id":"endothelin-3-human","title":"Endothelin-3 (Human)","description":"\u003cp\u003eET-3 (Human, Porcine, Rat, Rabbit, Mouse)\u003c\/p\u003e","brand":"peptanova","offers":[{"title":"0.1MG","offer_id":52785944428886,"sku":"4199-S","price":115.0,"currency_code":"EUR","in_stock":true},{"title":"0.5MG","offer_id":54225693016406,"sku":"4199-V","price":325.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/7940\/1302\/files\/4199.jpg?v=1777022289"},{"product_id":"big-endothelin-1-porcine-1-39","title":"Big Endothelin-1 (Porcine, 1 – 39)","description":"","brand":"peptanova","offers":[{"title":"0.1MG","offer_id":52785944461654,"sku":"4207-S","price":145.0,"currency_code":"EUR","in_stock":true},{"title":"0.5MG","offer_id":54225696358742,"sku":"4207-V","price":425.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/7940\/1302\/files\/4207.jpg?v=1777022289"},{"product_id":"big-endothelin-1-human-1-38","title":"Big Endothelin-1 (Human, 1 – 38)","description":"\u003cp\u003eBig ET-1 (1-38) (human)\u003c\/p\u003e","brand":"peptanova","offers":[{"title":"0.5MG","offer_id":52785944494422,"sku":"4208-V","price":425.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/7940\/1302\/files\/4208.jpg?v=1777022289"},{"product_id":"big-endothelin-1-rat-1-39","title":"Big Endothelin-1 (Rat, 1 – 39)","description":"","brand":"peptanova","offers":[{"title":"0.1MG","offer_id":52785944789334,"sku":"4266-S","price":155.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/7940\/1302\/files\/4266.jpg?v=1777022289"},{"product_id":"endothelin-2-human","title":"Endothelin-2 (Human)","description":"","brand":"peptanova","offers":[{"title":"0.1 mg","offer_id":52785962385750,"sku":"4209-S","price":115.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/7940\/1302\/files\/4209-s.jpg?v=1777022405"},{"product_id":"big-endothelin-2-human-1-38","title":"Big Endothelin-2 (Human, 1 – 38)","description":"","brand":"peptanova","offers":[{"title":"0.1 mg","offer_id":52785964876118,"sku":"4253-S","price":215.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/7940\/1302\/files\/4253-s.jpg?v=1777022406"},{"product_id":"suc-glu9-ala11-15-endothelin-1-8-21","title":"Suc-[Glu9, Ala11,15]-Endothelin-1 (8 – 21)","description":"\u003cp\u003eIRL 1620\u003c\/p\u003e","brand":"peptanova","offers":[{"title":"0.5 mg","offer_id":52785965891926,"sku":"4285-V","price":105.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/7940\/1302\/files\/4285-v.jpg?v=1777022405"},{"product_id":"big-endothelin-1-1-31-human","title":"Big Endothelin-1 (1 – 31) (Human)","description":"\u003cp\u003eBig ET-1 (1-31) (human, bovine)\u003c\/p\u003e","brand":"peptanova","offers":[{"title":"0.1 mg","offer_id":52785970118998,"sku":"4360-S","price":198.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/7940\/1302\/files\/4360-s.jpg?v=1777022434"}],"url":"https:\/\/peptanova.com\/de-intl\/collections\/endothelin-peptides.oembed","provider":"PeptaNova","version":"1.0","type":"link"}