AAF-CMK

AAF-CMK

5 mg
€85,00

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AAF-CMK
  • AAF-CMK
  • AAF-CMK

AAF-CMK

Produkt-ID: 3202

L-Alanyl- L-alanyl- L-phenylalanyl- chloromethane (Trifluoroacetate Form)

€85,00
exkl. 19% MwSt.
Beschreibung

Ala-Ala-Phe-CH2Cl | Ala-Ala-Phe-chloromethylketone

M.W. 339.82

C16H22N3O3Cl

102129-66-8

L-Alanyl- L-alanyl- L-phenylalanyl- chloromethane (Trifluoroacetate Form)

Irreversible Inhibitor for Tripeptidyl Peptidase II (Component of Giant Protease with Some Proteasome Function), Chymotrypsin and Chymase The synthetic serine protease inhibitor AAF-CMK, code 3202-v inhibits tripeptidyl peptidase II (TPP II) irreversibly and inhibits TPP I reversibly. Interference of this Tripeptidyl peptidase II (TPPII) with the chymotrypsin-like activity of the proteasome seems to be negligible. Inhibition of bleomycin hydrolase by inhibitor AAF-CMK is reported.

Synthetic Product

Referenzen:

1. R. Glas, M. Bogyo, J.S. McMaster, M. Gaczynska and H.L. Ploegh, Nature, 392, 618 (1998) 2. E. Geier, G. Pfeifer, M. Wilm, M. Lucchiari-Hartz, W. Baumeister, K. Eichmann and G. Niedermann, Science, 283, 978 (1999) 3. D. Leung, G. Abbenante and D.P. Fairlie, J. Med. Chem. 43, 305 (2000) 4. C. Rose et al, Neuropeptides 28, 157 (1995)

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