D-GsMTx-4

D-GsMTx-4

0.1 mg
€425,00

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D-GsMTx-4
  • D-GsMTx-4
  • D-GsMTx-4

D-GsMTx-4

Produkt-ID: 4525

Gly -D-Cys – D-Leu – D-Glu – D-Phe – D-Trp – D-Trp – D-Lys – D-Cys – D-Asn – D-Pro – D-Asn – D-Asp – D-Asp – D-Lys – D-Cys – D-Cys – D-Arg – D-Pro – D-Lys – D-Leu – D-Lys – D-Cys – D-Ser – D-Lys – D-Leu – D-Phe – D-Lys – D-Leu – D-Cys – D-Asn – D-Phe – D-Ser – D-Phe – NH2

€425,00
exkl. 19% MwSt.
Beschreibung

M.W. 4095.8

C185H273N49O45S6

Gly -D-Cys – D-Leu – D-Glu – D-Phe – D-Trp – D-Trp – D-Lys – D-Cys – D-Asn – D-Pro – D-Asn – D-Asp – D-Asp – D-Lys – D-Cys – D-Cys – D-Arg – D-Pro – D-Lys – D-Leu – D-Lys – D-Cys – D-Ser – D-Lys – D-Leu – D-Phe – D-Lys – D-Leu – D-Cys – D-Asn – D-Phe – D-Ser – D-Phe – NH2

Inhibitor of Mechanosensitive Ion Channels (e.g. Piezo2)

Synthetic Product (disulfide bonds between Cys2-Cys17, Cys9-Cys23 and Cys16-Cys30)

The purity is guaranteed to be higher than 99% by HPLC

Referenzen:

1. T.M. Suchyna, S.E. Tape, R.E.II Koeppe, O.S. Andersen, F. Sachs and P.A. Gottlieb, Nature, 430, 235 (2004) (Original) 2. C.L. Bowman, P.A. Gottlieb, T.M. Suchyna, Y.K. Murphy and F. Sachs, Toxicon, 49, 249 (2007) (Review) 3. C. Bae, F. Sachs and P.A. Gottlieb, Biochemistry, 50, 6295 (2011) (Piezo1 Channel Inhibitor) 4. R. Gnanasambandam, C. Ghatak, A. Yasmann, K. Nishizawa, F. Sachs, A.S. Ladokhin, S.I. Sukharev and T.M. Suchyna, Biophys J.,112, 31 (2017) (Mechanism Study of Inhibiting Mechanosensitive Ion Channels) 5. C. Alcaino, K. Knutson, P.A. Gottlieb, G. Farrugia and A. Beyder, Channels, 11, 245 (2017) (Piezo2 Channel Inhibitor) 6. M.M. Maneshi, L. Ziegler, F. Sachs, S.Z. Hua and P.A. Gottlieb, Sci. Rep., 8, 14267 (2018)

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