E-64-d

M.W. 342.44

C₁₇H₃₀N₂O₅

88321-09-09

[(2S,3S)-3-carboxyoxirane-2-carbonyl]-L-Leucine(3-methylbutyl)amide

Inhibitor for Thiol Protease (Cathepsin B/H/L, Calpain)E-64-d is the membrane permeable analog of the inhibitor E-64-c. By the chemical point of view, E-64-d is the ethylester of the Thiol Protease inhibitor E-64-c, which will released from E-64d after hydrolysis by intracellular esterases. It is reported that E-64-d inhibits degradation of plasma membrane proteins in endosomes and prevents both calpain upregulation and apoptosis. The inhibitor E-64-d offered from PeptaNova is chemically manufactued and not from biological origin. The standard inhibitor for cystein proteases E-64 is also available for prompt delivery ex stock.

Synthetic Product