Orexin B (Human)

M.W. 2899.3

C₁₂₃H₂₁₂N₄₄O₃₅S

205640-91-1

Arg – Ser – Gly – Pro – Pro – Gly – Leu – Gln – Gly – Arg – Leu – Gln – Arg – Leu – Leu – Gln – Ala – Ser – Gly – Asn – His – Ala – Ala – Gly – Ile – Leu – Thr – Met – NH2

Appetite-Boosting Peptide Orexin-B is a linear 28-residue peptide. The mutual sequence similarity to Orexin-A is high, especially in their C-terminal regions. Human, rat and mouse peptide sequences have been determined and the primary structure of orexin-A is completely conserved among these species including bovine. Orexin B stimulates food intake in a dose-dependent manner (3/30 nmol) for a few hours with slight duration difference. In addition, hypothalamic orexin mRNA is found to be up-regulated in fasting. Orexin-B and A are coded tandemly in the same mRNA flanked by the double basic amino acid residues.The same mRNA was isolated by another group from rat hypothalamic mRNA clone; the putative reading frames corresponding to orexin-A and B are named hypocretin based on the sequence similarity to secretin. [Proc. Natl. Acad. Sci., 95, 322 (1998)]

Synthetic Product

The purity is guaranteed to be higher than 99% by HPLC

Shipping | Storage | Stability Our product Orexin B will be shipped at room temperature. Information about product specific storage conditions can be found on the vial. Stock solutions should be stored at -20°C. Please avoid repeated freezing and thawing by preparing aliquots.