{"title":"Endothelin Peptides","description":"\u003cp\u003e\u003cspan\u003eSince Yanagisawa et al 1998 described the first \u003c\/span\u003e\u003cstrong\u003eEndothelin\u003c\/strong\u003e\u003cspan\u003e as a potent vasoconstrictor peptide, many other Endothelins and Endothelin related peptides have been isolated and reported. All \u003c\/span\u003e\u003cstrong\u003eEndothelin Peptides\u003c\/strong\u003e\u003cspan\u003e play a significant part in the regulation of the mammalian cardiovascular system and are involved in several signal transduction processes. Endothelin-1 (ET-1) and ET-3 are mainly produced from their precursor peptides in the vascular endothelium, whereas Endothelin-2 (ET-2) has been found in the kidney. All of these members of the Endothelin family shows two disulfide bonds between the cysteine resisidues 1 – 15 and 3 – 11. The genesis of Endothelin is a stepwise process. A 203 mer protein called Präproendothelin was cleaved in a first step by a specific peptidase into the oligo peptide Big-Endothelin. This proendothelin will be cleaved by endothelin-convertingenzyme into the biologically active Endothelin. The overexpression of endothelin peptides, particularly of ET-1 plays an important role in generation of heart diseases. PeptaNova offers 12 different Endothelin and Big-Endothelin peptides manufactured from Peptide Institute, Inc. Osaka. All offered Endothelin peptides are of synthetic origin, highly purified and tested of biological activity with dedicated essays. \u003c\/span\u003eSarafatoxin\u003cspan\u003e (B and C) isolated from the snake venom of Atractaspis engaddensis shows many similarities to the Endothelin peptides and can be ordered from PeptaNova as well.\u003c\/span\u003e\u003c\/p\u003e","products":[{"product_id":"endothelin-1-human","title":"Endothelin-1 (Human)","description":"\u003cp\u003eET-1 (Porcine, Canine, Rat, Mouse, Bovine)\u003c\/p\u003e","brand":"peptanova","offers":[{"title":"0.1MG","offer_id":52785944396118,"sku":"4198-S","price":115.0,"currency_code":"EUR","in_stock":true},{"title":"0.5MG","offer_id":54225692492118,"sku":"4198-V","price":285.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/7940\/1302\/files\/4198.jpg?v=1777022288"},{"product_id":"endothelin-3-human","title":"Endothelin-3 (Human)","description":"\u003cp\u003eET-3 (Human, Porcine, Rat, Rabbit, Mouse)\u003c\/p\u003e","brand":"peptanova","offers":[{"title":"0.1MG","offer_id":52785944428886,"sku":"4199-S","price":115.0,"currency_code":"EUR","in_stock":true},{"title":"0.5MG","offer_id":54225693016406,"sku":"4199-V","price":325.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/7940\/1302\/files\/4199.jpg?v=1777022289"},{"product_id":"big-endothelin-1-porcine-1-39","title":"Big Endothelin-1 (Porcine, 1 – 39)","description":"","brand":"peptanova","offers":[{"title":"0.1MG","offer_id":52785944461654,"sku":"4207-S","price":145.0,"currency_code":"EUR","in_stock":true},{"title":"0.5MG","offer_id":54225696358742,"sku":"4207-V","price":425.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/7940\/1302\/files\/4207.jpg?v=1777022289"},{"product_id":"big-endothelin-1-human-1-38","title":"Big Endothelin-1 (Human, 1 – 38)","description":"\u003cp\u003eBig ET-1 (1-38) (human)\u003c\/p\u003e","brand":"peptanova","offers":[{"title":"0.5MG","offer_id":52785944494422,"sku":"4208-V","price":425.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/7940\/1302\/files\/4208.jpg?v=1777022289"},{"product_id":"big-endothelin-1-rat-1-39","title":"Big Endothelin-1 (Rat, 1 – 39)","description":"","brand":"peptanova","offers":[{"title":"0.1MG","offer_id":52785944789334,"sku":"4266-S","price":155.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/7940\/1302\/files\/4266.jpg?v=1777022289"},{"product_id":"endothelin-2-human","title":"Endothelin-2 (Human)","description":"","brand":"peptanova","offers":[{"title":"0.1 mg","offer_id":52785962385750,"sku":"4209-S","price":115.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/7940\/1302\/files\/4209-s.jpg?v=1777022405"},{"product_id":"big-endothelin-2-human-1-38","title":"Big Endothelin-2 (Human, 1 – 38)","description":"","brand":"peptanova","offers":[{"title":"0.1 mg","offer_id":52785964876118,"sku":"4253-S","price":215.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/7940\/1302\/files\/4253-s.jpg?v=1777022406"},{"product_id":"suc-glu9-ala11-15-endothelin-1-8-21","title":"Suc-[Glu9, Ala11,15]-Endothelin-1 (8 – 21)","description":"\u003cp\u003eIRL 1620\u003c\/p\u003e","brand":"peptanova","offers":[{"title":"0.5 mg","offer_id":52785965891926,"sku":"4285-V","price":105.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/7940\/1302\/files\/4285-v.jpg?v=1777022405"},{"product_id":"big-endothelin-1-1-31-human","title":"Big Endothelin-1 (1 – 31) (Human)","description":"\u003cp\u003eBig ET-1 (1-31) (human, bovine)\u003c\/p\u003e","brand":"peptanova","offers":[{"title":"0.1 mg","offer_id":52785970118998,"sku":"4360-S","price":198.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/7940\/1302\/files\/4360-s.jpg?v=1777022434"}],"url":"https:\/\/peptanova.com\/en-eu\/collections\/endothelin-peptides.oembed","provider":"PeptaNova","version":"1.0","type":"link"}