Calcicludine

Calcicludine

0.1 mg
€255,00

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Calcicludine
  • Calcicludine
  • Calcicludine

Calcicludine

Product ID: 4310

Trp – Gln – Pro – Pro – Trp – Tyr – Cys – Lys – Glu – Pro – Val – Arg – Ile – Gly – Ser – Cys – Lys – Lys – Gln – Phe – Ser – Ser – Phe – Tyr – Phe – Lys – Trp – Thr – Ala – Lys – Lys – Cys – Leu – Pro – Phe – Leu – Phe – Ser – Gly – Cys – Gly – Gly – Asn – Ala – Asn – Arg – Phe – Gln – Thr – Ile – Gly – Glu – Cys – Arg – Lys – Lys -Cys – Leu – Gly – Lys

€255,00
excl. 19% VAT
Description

CaC (Green Mamba, Dendroapsis angusticeps)

M.W. 6980.1

C321H476N86O78S6

Trp – Gln – Pro – Pro – Trp – Tyr – Cys – Lys – Glu – Pro – Val – Arg – Ile – Gly – Ser – Cys – Lys – Lys – Gln – Phe – Ser – Ser – Phe – Tyr – Phe – Lys – Trp – Thr – Ala – Lys – Lys – Cys – Leu – Pro – Phe – Leu – Phe – Ser – Gly – Cys – Gly – Gly – Asn – Ala – Asn – Arg – Phe – Gln – Thr – Ile – Gly – Glu – Cys – Arg – Lys – Lys -Cys – Leu – Gly – Lys

Calcicludine is a neuronal L-type Ca2+ Channel Blocker and was originally isolated from the green mamba venom. Calcicludine shows a structure-activity relationship to Dendrotoxin IThe biological activity of Calcicludine is examined by the Division of Pharmacology, Peptide Institute, Inc.

Synthetic Product (disulfide bonds between Cys7-Cys57, Cys16-Cys40 and Cys32-Cys53 )

The purity is guaranteed to be higher than 99% by HPLC

References:

1. H. Schweitz, C. Heurteaux, P. Bois, D. Moinier, G. Romey and M. Lazdunski, Proc. Natl. Acad. Sci. USA, 91, 878 (1994) (Original) 2. H. Nisho, J. Nishiuchi, T. Inui, M. Nakao, T.X. Watanabe, T. Kimura and S. Sakakibara, Peptide Chemistry, 1985, 113 (1996) (Chem. Synthesis of Calcicludine and Pharmacology) 3. O.D. Uchitel, Toxicon, 35, 1161 (1997) (Review)

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