Chlorotoxin

Chlorotoxin

0.5 mg
€340,00

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Chlorotoxin
  • Chlorotoxin
  • Chlorotoxin

Chlorotoxin

Product ID: 4282

Met – Cys – Met – Pro – Cys – Phe – Thr – Thr – Asp – His – Gln – Met – Ala – Arg – Lys – Cys – Asp – Asp – Cys – Cys – Gly – Gly – Lys – Gly – Arg – Gly – Lys – Cys – Tyr – Gly – Pro – Gln – Cys – Leu – Cys – Arg – NH2

€340,00
excl. 19% VAT
Description

(Scorpion, Leiurus quinquestriatus)

M.W. 3995.7

C158H249N53O47S11

Met – Cys – Met – Pro – Cys – Phe – Thr – Thr – Asp – His – Gln – Met – Ala – Arg – Lys – Cys – Asp – Asp – Cys – Cys – Gly – Gly – Lys – Gly – Arg – Gly – Lys – Cys – Tyr – Gly – Pro – Gln – Cys – Leu – Cys – Arg – NH2

Chlorotoxin is a small conductance Cl– Channel Blocker with anti invasive effect by inhibiting Gelatinase AThis 36 mer neuropeptide toxin was originally isolated from the venom of the scorpion Leiurus quinquestriatus. Chlorotoxin (CTx, ClTx) is a new interesting tool in cancer research, due to its antiinvasive effect by binding to the surface of glioma cells. Fluorescence and Iodine labeling of this peptide opens new aspects in cancer diagnostics. The synthetic Chlorotoxin (CTx), offered from PeptaNova is chemically synthesized and not recombinant expressed in E.Coli.

Synthetic Product (disulfide bonds between Cys2-Cys19, Cys5-Cys28, Cys16-Cys33 and Cys20-Cys35)

The purity is guaranteed to be higher than 99% by HPLC

References:

1. J.A. DeBin, J.E. Maggio and G.R. Strichartz, Am. J. Physiol., 264, C361 (1993) (Original) 2. J. Najib, P. Sautiere, J.C. Gesquiere and A. Tartar, In. Inovation and Perspective in Solid Phase Synthesis, (R. Epton, ed.) (1994) pp. 615-618 (Original, Amide) 3. G. Lippens, J. Najib, S.J. Wodak and A. Tatar, Biochemistry, 34, 13 (1995) (NMR Structure of Chlorotoxin) 4. L. Soroceanu, Y. Gillespie, M.B. Khazaeli and H. Sontheimer, Cancer Res., 58, 4871 (1998) (Pharmacology of Chlorotoxin)

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