Dermcidin-1L (Human)

Product ID: 4454

Ser- Ser- Leu- Leu- Glu- Lys- Gly- Leu- Asp- Gly- Ala- Lys- Lys- Ala- Val- Gly- Gly- Leu- Gly- Lys- Leu- Gly- Lys- Asp- Ala- Val- Glu- Asp- Leu- Glu- Ser- Val- Gly- Lys- Gly- Ala- Val- His- Asp- Val- Lys- Asp- Val- Leu- Asp- Ser- Val- Leu

€180,00

excl. 19% VAT

Description

DCD-1L (Human)

M.W. 4818.4

C₂₁₀H₃₅₉N₅₇O₇₁

Dermcidin-1L is an antimicrobial peptide found in human sweat. DCD-1L is formed from a dermcidin precursor by proteolytic cleavage. This peptide belongs to the rare group of Anionic antimicrobial peptides (AAMP), especially in humans. It was reported that in studies using DCD-1L, Dermcidin-1L was active against Gram-positive and negative bacteria and fungi. Dermcidin-1L activates human keratinocytes. DCD-1L does not show membrane permeability.

Synthetic Product

The purity of our antimicrobial peptide Dermcidin-1L | DCD-1L is guaranteed to be higher than 99% by HPLC

References:

1. B. Schittek, R. Hipfel, B. Sauer, J. Bauer, H. Kalbacher, S. Stevanovic, M. Schirle, K. Schroeder, N. Blin, F. Meier, G. Rassner C. Garbe, Nat. Immunol. 2, 1133 (2001) (Original; antimicrobial peptide) 2. S. Rieg, H. Steffen, S. Seeber, A. Humeny, H. Kalbacher, K. Dietz, C. Garbe and B. Schittek, J. Immunol. 174, 8003 (2005) (endogenous form) 3. H. Steffen, S.Rieg, I. Wiedemann, H. Kalbacher, M. Deeg, H.-G. Sahl, A. Peschel, F. Götz, C. Garbe and B. Schittek, Antimicrob. Agents Chemother., 50, 2608 (2006) (Pharmacol) 4. F. Niyonsaba, A. Suzuki, H. Ushio, I. Nagaoka, H. Ogawa and K. Okumura, Br. J. Dermatol, 160, 243 (2009) (Pharmacology) 5. I. Senyurek, M. Paulmann, T. Sinnberg, H. Kalbacher, M. Deeg, T. Gutsmann, M. Hermes, T. Kohler, F. Götz, C. Wolz, A. Peschel and B. Schittek, Antimicrob. Agents Chemother., 53, 2499 (2009) (Pharmacology)

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