ProTX-II (Protoxin-II)

Product ID: 4450

Tyr- Cys- Gln- Lys- Trp- Met- Trp- Thr- Cys- Asp- Ser- Glu- Arg- Lys- Cys- Cys- Glu- Gly- Met- Val- Cys- Arg- Leu- Trp- Cys- Lys- Lys- Lys- Leu- Trp

€150,00

excl. 19% VAT

Description

(Tarantula, Thrixopelma pruriens)

M.W. 3826.60

C₁₆₈H₂₅₀N₄₆O₄₁S₈

Tyr- Cys- Gln- Lys- Trp- Met- Trp- Thr- Cys- Asp- Ser- Glu- Arg- Lys- Cys- Cys- Glu- Gly- Met- Val- Cys- Arg- Leu- Trp- Cys- Lys- Lys- Lys- Leu- Trp

Na+ Channel (Especially Nav1.7) / Ca2+ Channel Blocker (Gating Modifier) ProTx-II was originally isolated from the venom of the tarantula Thrixopelma pruriens. Potent channel blocker with high selectivity for Nav1.7 channel. ProTx-II is a potent inhibitor for tetrodotoxin-sensitive and tetrodotoxin-resistant voltage-gated sodium channels. The Nav1 type channels exists in different sub types and ProTx-II shows a special affinity to the Nav1.7 channel which is responsible for pain processing.

Synthetic Product (disulfide bonds between Cys2– Cys16, Cys9– Cys21 and Cys15– Cys25 ) and not from animal origin

The purity is guaranteed to be higher than 99% by HPLC

References:

1. R.E. Middleton, V.A. Warren, R.L. Kraus, J.C. Hwang, C.J. Liu, G. Dai, R.M. Brochu, M.G. Kohler, Y.-D. Gao, V.M. Garsky, M.J. Bogusky, J.T. Mehl, C.J. Cohen and M.M. Smith, Biochemistry, 41, 14734 (2002) (Original) 2. J.J. Smith, T.R. Cummins, S. Alphy and K.M. Blumenthal, J. Biol. Chem., 282, 12687 (2007) (Pharmacol.; Novel Toxin Binding Site Coupled to NaV Activation) 3. W.A. Schmalhofer, J. Calhoun, R. Burrows, T. Bailey, M.G. Kohler, A.B. Weinglass, G.J. Kaczorowski, M.L. Garcia, M. Koltzenburg and B.T. Priest, Mol. Pharmacol., 74, 1476 (2008) (Pharmacol.; Inhibition of Nav1.7 Channel) 4. B.T. Priest, K.M. Blumenthal, J.J. Smith, V.A. Warren, and M.M. Smith, Toxicon, 49, 194 (2007) (Review)

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