Urotensin II (Rat);

Urotensin II (Rat);

0.5 mg
€195,00

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Urotensin II (Rat);
  • Urotensin II (Rat);
  • Urotensin II (Rat);

Urotensin II (Rat);

Product ID: 4371

Pyr – His – Gly – Thr – Ala – Pro – Glu – Cys – Phe – Trp – Lys – Tyr – Cys – Ile

€195,00
excl. 19% VAT
Description

[Pyr110]-Prepro-Urotensin II (Rat, 110-123)

M.W. 1663.9

C77H102N18O20S2

Pyr – His – Gly – Thr – Ala – Pro – Glu – Cys – Phe – Trp – Lys – Tyr – Cys – Ile

Urotensin II (Rat) is a potent Vasoconstrictor with negative inotropic effects. Urotensin II (U-II) is a disulfide-linked small peptide initially isolated from fish urophysis. Subsequently, the cDNA sequence encoding the human U-II precursor was determined, and the corresponding mRNA was found to exist predominantly in spinal cord [Proc. Natl. Acad. Sci. USA, 95, 15803 (1998)]. Human U-II, then, was revealed to be an agonist for the orphan receptor GPR14 and exerts a strong vasoconstricting activity in the isolated thoracic aorta of rat [Nature, 401, 282 (1999)]. The potency of vasoconstriction of U-II is an order of magnitude greater than that of endothelin-1, making human U-II the most potent mammalian vasoconstrictor identified so far.Following the sequence determination of human U-II, the same group reported the corresponding rat peptide cDNA sequence [FEBS Lett., 457, 28 (1999)]. When we look at the deduced peptide sequence of rat prepro-U-II, there are two double basic sites at its C-terminal region, which might be the enzymatic cleavage sites for yielding the mature peptide of rat U-II. We chose the shorter peptide of 14 amino acid residues with pyroglutamic acid modification for Gln110 as the possible candidate for rat U-II and chemically synthesized it. Synthetic [Pyr110 ]-prepro-U-II (110-123) was confirmed to have a vasoconstricting activity as potent as that of human peptide in the isolated thoracic aorta of rat (unpublished result). Therefore, we tentatively named this peptide rat U-II (Urotensin II rat) in our catalog, although the mature form of rat U-II remains to be determined. Recently, Davenport AP & Maguire JJ have predicted the sequence of rat or mouse U-II as prepro-U-II (110-123) [Trends Pharmacol. Sci., 21, 80 (2000)].

Synthetic Product (Disulfide bond between Cys8– Cys13)

This compound has some inherent instability. The purity is guaranteed to be higher than 97% by HPLC

References:

1. Y. Coulouarn, S. Jégou, H. Tostivint, H. Vaudry, and I. Lihrmann, FEBS Lett, 457, 28 (1999) (Original) 2. S.M. Gardiner, J.E. March, P.A. Kemp, A.P. Davenport, and T. Bannett, Br. J. Pharmacol, 132, 1625 (2001) (Pharmacol.)

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