Ac-YVAD-CHO

Ac-YVAD-CHO

5 mg
€152,00

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Ac-YVAD-CHO
  • Ac-YVAD-CHO
  • Ac-YVAD-CHO

Ac-YVAD-CHO

Product ID: 3165

Acetyl- L-tyrosyl- L-valyl- L-alanyl- L- aspart-1-al

€152,00
excl. 19% VAT
Description

M.W. 492.53

C23H32N4O8

143313-51-3

Acetyl- L-tyrosyl- L-valyl- L-alanyl- L- aspart-1-al

Specific, reversible Inhibitor for Caspase-1 The tetrapeptide aldehyd Ac-YVAD-CHO is a reversible inhibitor for caspase-1 and is often used as a control substance for enzyme inhibition. This inhibitor is also used to block IL-18 production. Ac-YVAD-CHO inhibits ICE, interleukin-1β converting enzyme reversible, whereas Ac-YVAD-CMK binds irreversible at the same target. The less specific z-vad-fmk is also available by PeptaNova as well as the fluorogenic enzyme substrate Ac-YVAD-AMC. All these commonly used caspase substrates and inhibitors are available from our stock in Sandhausen, Germany.

Synthetic Product

References:

1. N.A. Thornberry, H.G. Bull, J.R. Calaycay, K.T. Chapman, A.D. Howard, M.J. Kostura, D.K. Miller, S.M. Molineaux, J.R. Weidner, J. Aunins, K.O. Elliston, J.M. Ayala, F.J. Casano, J. Chin, G.J.-F. Ding, L.A. Egger, E.P. Gaffney, G. Limjuco, O.C. Palyha, S.M. Raju, A.M. Rolando, J.P. Salley, T.-T. Yamin, T.D. Lee, J.E. Shively, M. MacCross, R.A. Mumford, J.A. Schmidt and M.J. Tocci, Nature, 356, 368 (1992) 2. S.M. Molineaux, F.J. Casano, A.M. Rolando, E.P. Peterson, G. Limjuco, J. Chin, P.R. Griffin, J.R. Calaycay, G.J.-F. Ding, T.-T. Yamin, O.C. Palyha, S. Luell, D. Fletcher, D.K. Miller, A.D. Howard, N.A. Thornberry and M.J. Kostura, Proc. Natl. Acad. Sci. USA, 90, 1809 (1993)

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