Big Endothelin-1 (1 – 31) (Human)

M.W. 3628.2

C₁₆₂H₂₃₆N₃₈O₄₇S₅

133972-52-8

Cys – Ser – Cys – Ser – Ser – Leu – Met – Asp – Lys – Glu – Cys – Val – Tyr – Phe – Cys – His – Leu – Asp – Ile – Ile – Trp – Val – Asn – Thr – Pro – Glu – His – Val – Val – Pro – Tyr

Big Endothelin-1 (1-31) is an endogenous form of Endothelin-1. The 31 mer oligopeptide is generated by chymase hydolysation from its precursor. This conversation process can be blocked with Phosphoramidon, which is a potent endothelin-converting-enzyme inhibitor. The conversation from Big Endothelin-1 (1-31) into Endothelin 1 will not be effected.The biological activity of Big Endothelin-1 (1 – 31) is examined by the Division of Pharmacology, Peptide Institute, Inc.

Synthetic Product (disulfide bonds between Cys1-Cys15 and Cys3-Cys11)

The purity is guaranteed to be higher than 99% by HPLC