Charybdotoxin

M.W. 4295.9

C₁₇₆H₂₇₇N₅₇O₅₅S₇

95751-30-7

Pyr – Phe – Thr – Asn – Val – Ser – Cys – Thr – Thr – Ser – Lys – Glu – Cys – Trp – Ser – Val – Cys – Gln – Arg – Leu – His – Asn – Thr – Ser – Arg – Gly – Lys – Cys – Met – Asn – Lys – Lys – Cys – Arg – Cys – Tyr – Ser

Charybdotoxin is a selective and high effective Ca2+-Activated K+ Channel BlockerThe biological activity of Charybdotoxin is examined by the Division of Pharmacology, Peptide Institute, Inc.The synthetic peptide toxin Charybdotoxin (ChTx, CTx) composed of 37 amino acid residues was originally isolated from the venom of the Scorpion, Leiurus quinquestriatus hebraeus. Charybdotoxin is a highly efficient ion channel blocker with effects on mitogen-induced proliferationon of peripheral T lymphocytes. CTx altered the activity of retinal ganglion cells in the dark- and light-adapted mouse retina. Charybdotoxin (ChTx, CTx) from Peptide Institute is manufactured by chemical synthesis and in not isolated from biological sources.

Synthetic Product (disulfide bonds between Cys7-Cys28, Cys13-Cys33 and Cys17-Cys35 )

The purity is guaranteed to be higher than 99% by HPLC