Endothelin-1 (Human)

Endothelin-1 (Human)

0.1MG
€115,00

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Endothelin-1 (Human)
  • Endothelin-1 (Human)
  • Endothelin-1 (Human)

Endothelin-1 (Human)

Product ID: 4198

Cys – Ser – Cys – Ser – Ser – Leu – Met – Asp – Lys – Glu – Cys – Val – Tyr – Phe – Cys – His – Leu – Asp – Ile – Ile – Trp

€115,00
excl. 19% VAT
Description

ET-1 (Porcine, Canine, Rat, Mouse, Bovine)

M.W. 2491.9

C109H159N25O32S5

117399-94-7

Cys – Ser – Cys – Ser – Ser – Leu – Met – Asp – Lys – Glu – Cys – Val – Tyr – Phe – Cys – His – Leu – Asp – Ile – Ile – Trp

Endothelin-1 (ET-1) is described as a biologicaly active peptide of 21 aminoacid residues, which contains 2 disulfide bridges. This endothelium-derived peptide shows high vasoconstrictor and proliferative attributes. Failures in the regulation process of Endothelin-1 (ET-1) may be one reason for hypertension and some other cardiovascular diseases.The biological activity of Endothelin-1 is examined by the Division of Pharmacology, Peptide Institute, Inc.ET-1 is distributed through Peptide Institute, Inc. under the license of Takeda Pharmaceutical Company, Ltd. and the National Institute of Advanced Industrial Scienence & Technology (AIST)

Synthetic Product (disulfide bonds between Cys1-Cys15 and Cys3-Cys11)

The purity is guaranteed to be higher than 99% by HPLC

References:

1. M. Yanagisawa, H. Kurihara, S. Kimura, Y. Tomobe, M. Kobayashi, Y. Mitsui, Y. Yazaki, K. Goto and M. Masaki, Nature, 332, 411 (1988) (Original) 2. A. Inoue, M. Yanagisawa, S. Kimura, Y. Kasuya, T. Miyauchi, K. Goto and T. Masaki, Proc. Natl. Acad. Sci. USA, 86, 2863 (1989) (Naming) 3. T.X. Watanabe, Y. Itahara, K. Nakajima, S. Kumagaye, T. Kimura and S. Sakakibara, J. Cardiovasc. Pharmacol., 17 (Suppl. 7), S5 (1991) (Pharmacology of Endothelin-1)

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