Huwentoxin-IV

Huwentoxin-IV

0.1 mg
€195,00

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Huwentoxin-IV
  • Huwentoxin-IV
  • Huwentoxin-IV

Huwentoxin-IV

Product ID: 4455

Glu – Cys – Leu – Glu – Ile – Phe – Lys – Ala – Cys – Asn – Pro – Ser – Asn – Asp – Gln – Cys – Cys – Lys – Ser – Ser – Lys – Leu – Val – Cys – Ser – Arg – Lys – Thr – Arg – Trp – Cys – Lys – Tyr – Gln – Ile – NH2

€195,00
excl. 19% VAT
Description

HWTX-IV
(Chinese Bird Spider, Ornithoctonus huwena)

M.W. 4106.8

C174H278N52O51S6

Glu – Cys – Leu – Glu – Ile – Phe – Lys – Ala – Cys – Asn – Pro – Ser – Asn – Asp – Gln – Cys – Cys – Lys – Ser – Ser – Lys – Leu – Val – Cys – Ser – Arg – Lys – Thr – Arg – Trp – Cys – Lys – Tyr – Gln – Ile – NH2

Neuronal Tetrodotoxin-Sensitive Na+-Channel Blocker Huwentoxin-IV, HWTX-IV) was originally isolated from the Chinese Bird Spider venom. The 35 residue peptide build 3 disulfid bridges and is a potent inhibitor of neuronal voltage gated sodium channels.

Synthetic ProductSynthetic Product (Disulfide bonds between Cys2 – Cys17, Cys9 – Cys24, and Cys16 – Cys31)

The purity of our product Huwentoxin-IV is guaranteed to be higher than 99% by HPLC

References:

1. K. Peng, Q. Shu, Z. Liu and S. Liang, J. Biol. Chem., 277, 47564 (2002) (Original) 2. J. Diao, Y. Lin, J. Tang and S. Liang, Toxicon, 42, 715 (2003) (cDNA Seq.) 3. Y. Xiao, J.-P. Bingham, W. Zhu, E. Moczydlowski, S. Liang and T.R. Cummins, J. Biol. Chem., 283, 27300 (2008) (Pharmacology) 4. Y. Xiao, X. Luo, F. Kuang, M. Deng, M. Wang, X. Zeng and S. Liang, Toxicon, 51, 230 (Pharmacol.)

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