Ac-YVAD-CMK

Ac-YVAD-CMK

5 mg
€165,00

You can create a Quote after adding product to the Cart.

Skip to product information
Ac-YVAD-CMK
  • Ac-YVAD-CMK
  • Ac-YVAD-CMK

Ac-YVAD-CMK

Product ID: 3180

Acetyl- L-tyrosyl- L-valyl- L-alanyl- L-aspart-1-yl-Chloromethane

€165,00
excl. 19% VAT
Description

Ac-YVAD-Chloromethylketone

M.W. 541.00

C24H33N4O8Cl

178603-78-6

Acetyl- L-tyrosyl- L-valyl- L-alanyl- L-aspart-1-yl-Chloromethane

Irreversible Inhibitor for Caspase-1 Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CH2Cl) is used as an irreversible inhibitor for Caspase-1, instead of the pseudo acid (aldehyde) Ac-YVAD-CHO which inhibits caspase reversible. The caspase-1 inhibitor Ac-YVAD-CMK is of interest in reasearch of sepsis and endotoxic shock.

Synthetic Product

References:

1. Y.A. Lazebnik, S.H. Kaufmann, S. Desnoyers, G.G. Poirier and W.C. Earnshaw, Nature, 371, 346 (1994) 2. M. Enari, H. Hug and S. Nagata, Nature, 375, 78 (1995) 3. C.E. Milligan, D. Prevette, H. Yaginuma, S. Homma, C. Cardwell, L.C. Fritz, K.J. Tomaselli, R.W. Oppenheim and L.W. Schwartz, Neuron, 15, 385 (1995) 4. E. Fujita, T. Mukasa, T. Tsukahara, K. Arahata, S. Omura and T. Momoi, Biochem. Biophys. Res. Commun, 224, 74 (1996)

You may also like