APETx2

APETx2

0.1 mg
€165,00

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APETx2
  • APETx2
  • APETx2

APETx2

Product ID: 4472

Gly- Thr- Ala- Cys- Ser- Cys- Gly- Asn- Ser- Lys- Gly- Ile- Tyr- Trp- Phe- Tyr- Arg- Pro- Ser- Cys- Pro- Thr- Asp- Arg- Gly- Tyr- Thr- Gly- Ser- Cys- Arg- Tyr- Phe- Leu- Gly- Thr- Cys- Cys- Thr- Pro- Ala- Asp

€165,00
excl. 19% VAT
Description

Synthetic peptide toxin originally isolated from the venome of the sea anemone Anthopleura elegantissima

M.W. 4561

C196H280N54O61S6

Gly- Thr- Ala- Cys- Ser- Cys- Gly- Asn- Ser- Lys- Gly- Ile- Tyr- Trp- Phe- Tyr- Arg- Pro- Ser- Cys- Pro- Thr- Asp- Arg- Gly- Tyr- Thr- Gly- Ser- Cys- Arg- Tyr- Phe- Leu- Gly- Thr- Cys- Cys- Thr- Pro- Ala- Asp

APETx2 is a selective blocker of the Acid-Sensing Ion Channel, ASIC3 The homodimer proton gated channel ASIC3 is involved in several pain transmitting processes. pH dependent blocking of the ASIC3 channel by APETx2 shows analgesic effects against acid-induced and inflammatory pain.APETx2 is manufactured by chemical solid phase peptide synthesis and is carefully purified by reversed phase HPLC. The ion channel blocker is not of recombinant origin expressed in e-coli, therefore cross contamination with e-coli proteins are not be feared.

Synthetic Product (reported disulfide bonds between Cys4 – Cys37, Cys6 – Cys30 and Cys20 – Cys38 )

The purity is guaranteed to be higher than 99% by HPLC

Shipping | Storage | Stability Ion Channel Blocker APETx2 will be shipped at room temperature. Information about product specific storage conditions will be found on the vial.

References:

1. S. Diochot, A. Baron, L.D. Rash, E. Deval, P. Escoubas, S. Scarzello, M. Salinas, and M. Lazdunski,EMBO J., 23, 1516 (2004).(Original ; Primary Structure, S-S Bond & Pharmacol.) 2. B. Chagot, P. Escoubas, S. Diochot, C. Bernard, M. Lazdunski, and H. Darbon,Protein Sci., 14, 2003 (2005). (NMR structure) 3. S. Diochot, M. Salinas, A. Baron, P. Escoubas, and M. Lazdunski,Toxicon 49, 271 (2007). (Pharmacol.) 4. W.-L. Wu, C.-F. Cheng, W.-H. Sun, C.-W. Wong, and C.-C. Chen,Pharmacol. Ther., 134, 127 (2012). (Review; Pharmacol.)

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