DAPT

DAPT

5 mg
€98,00

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DAPT
  • DAPT
  • DAPT

DAPT

Product ID: 3219

(3,5- Difluorophenylacetyl)- L-alanyl- L-2-phenylglycine t-butyl ester

€98,00
excl. 19% VAT
Description

(3,5-Difluorophenylacetyl)-Ala-Phg-OBut | (3,5-Difluorophenylacetyl)-Ala-Phg-OtBu

M.W. 432.46

C23H26N2O4F2

(3,5- Difluorophenylacetyl)- L-alanyl- L-2-phenylglycine t-butyl ester

Inhibitor for γ-Secretase The abbreviation DAPT stands for Difluorophenylacetyl)-alanyl-phenylglycine-t-butyl-ester. DAPT is a commonly used cell permeable inhibitor for enzymes of the secretase family and may be a helpful tool in the study of β-amyloid formation in Alzheimer´s disease. Notch signaling in hybrid human-mouse fetal thymus organ culture was inhibited by treatment with DAPT. This γ-Secretase inhibitor may be useful in research of autoimmune diseases. The protected dipeptide ester offered in vials of 5 mg is of synthetic origin. DAPT is soluble in DMSO, Ethanol or other organic solvents.

Synthetic Product

References:

1. H.F. Dovey et al, J. Neurochem., 76, 173 (2001). (DAPT | Functional γ-Secretase Inhibitor in brain) 2. A.Y. Kornilova, C. Das and M.S. Wolfe, J. Biol. Chem., 278, 16470 (2003). (Comparison of in Cells and Cell-Free Activity) 3. Sousuke Yagishita, Maho Morishima-Kawashima, Yu Tanimura, Shoichi Ishiura and Yasuo Ihara, Biochemistry, 2006, 45 (12), pp 3952–3960 (DAPT-Induced Intracellular Accumulations of Longer Amyloid β-Proteins: Further Implications for the Mechanism of Intramembrane Cleavage by γ-Secretase)

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