Imperatoxin A

Imperatoxin A

0.1 mg
€225,00

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Imperatoxin A
  • Imperatoxin A
  • Imperatoxin A

Imperatoxin A

Product ID: 4343

Gly – Asp – Cys – Leu – Pro – His – Leu – Lys – Arg – Cys – Lys – Ala – Asp – Asn – Asp – Cys – Cys – Gly – Lys – Lys – Cys – Lys – Arg – Arg – Gly – Thr – Asn – Ala – Glu – Lys – Arg – Cys – Arg

€225,00
excl. 19% VAT
Description

IpTXa
(Scorpion, Pandinus imperator)

M.W. 3758.4

C148H254N58O45S6

172451-37-5

Gly – Asp – Cys – Leu – Pro – His – Leu – Lys – Arg – Cys – Lys – Ala – Asp – Asn – Asp – Cys – Cys – Gly – Lys – Lys – Cys – Lys – Arg – Arg – Gly – Thr – Asn – Ala – Glu – Lys – Arg – Cys – Arg

Activator of Ca2+ Release Channels / Ryanodine Receptors Imperatoxin A is a 33 residue peptide toxin originally isolated from the venom of Scorpion, Pandinus imperator. IpTXa is a potent modifier for the RyR1 and RyR3 channels with high affinity. Imperatoxin A enhances calcium release and is a strong agonist of ryanodine receptors.

Synthetic Product (disulfide bonds between Cys3-Cys17, Cys10-Cys21 and Cys16-Cys32)

The purity of Imperatoxin A is guaranteed to be higher than 99% by HPLC

Shipping | Storage | Stability Our product Imperatoxin A (IpTXa) will be shipped at room temperature. Information about product specific storage conditions will be found on the vial. Stock solutions should be stored at -20°C. Please avoid repeated freezing and thawing by preparing aliquots.

References:

1. H.H. Valdivia, M.S. Kirby, W.J. Lederer and R.Coronado, Proc. Natl. Acad. Sci. USA, 89, 12185 (1992) (Pharmacol.) 2. R. El-Hayek, A.J. Lokuta, C. Arévalo and H.H. Valdivia, J. Biol. Chem., 270, 28692 (1995) (Pharmacol) 3. F.Z. Zamudio, G.B. Gurrola, C. Arévalo, R. Sreekumar, J.W. Walker, H.H. Valdivia and L.D. Possani, FEBS Lett., 405, 385 (1997) (Original; Structure) 4. K. Takeuchi, J.I. Kim, H. Takahashi, K. Sato and I. Shimada, Peptide Science 1999, 307, (2000) (S-S Bond)

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