ω-Conotoxin MVIIC

ω-Conotoxin MVIIC

0.1MG
€130,00

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ω-Conotoxin MVIIC
  • ω-Conotoxin MVIIC
  • ω-Conotoxin MVIIC

ω-Conotoxin MVIIC

Product ID: 4283

Cys – Lys – Gly – Lys – Gly – Ala – Pro – Cys – Arg – Lys – Thr – Met – Tyr – Asp – Cys – Cys – Ser – Gly – Ser – Cys – Gly – Arg – Arg – Gly – Lys – Cys – NH2

€130,00
excl. 19% VAT
Description

(Marine Snail, Conus magus)

M.W. 2749.3

C106H178N40O32S7

147794-23-8

Cys – Lys – Gly – Lys – Gly – Ala – Pro – Cys – Arg – Lys – Thr – Met – Tyr – Asp – Cys – Cys – Ser – Gly – Ser – Cys – Gly – Arg – Arg – Gly – Lys – Cys – NH2

P / Q-type Ca2+ Channel BlockerThe synthetic peptide toxin omega-Conotoxin MVIIC is a P/Q-type calcium channels with high affinity. It blocks as well N-type calcium channels with low affinity. omega-Conotoxin MVIIC labeled with [125I] is used as diagnostical tool in the research of Lambert-Eaton myasthenic syndrome.ω-Conotoxin MVIIC can be shipped to autorized end users with own application labs only. We will need a dedicated end user declaration for this item and cannot ship conotoxin to trading companies!

Synthetic Product (disulfide bonds between Cys1-Cys16, Cys8-Cys20 and Cys15-Cys26)

The purity is guaranteed to be higher than 99% by HPLC

References:

1. R.R. Hillyard, V.D. Monje, I.M. Mintz, B.P. Bean, L. Nadasdi, J. Ramachandran, G. Miljanich, A. Azimi-Zoonooz, J.K.McIntosh, L.J. Cruz, J.S. Imperial and B.M. Olivera, Neuron, 9, 69 (1992) (Original; cDNA and Pharmacol.) 2. M.E. Adams, R.A. Myers, J.S. Imperial, and B.M. Olivera, Biochemistry, 32, 12566 (1993) (Pharmacol.) 3. W.A. Sather, T. Tanabe, J.F. Zhang, Y. Mori, M.E. Adams and R.W. Tsien, Neuron, 11, 291 (1993) (Pharmacol.) 4. D.B. Wheeler, A. Randall and R.W. Tsien, Science, 264, 107 (1994) (Pharmacol.)

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