Psalmotoxin 1 | PcTX1

Product ID: 4435

Glu- Asp- Cys- Ile- Pro- Lys- Trp- Lys- Gly- Cys- Val- Asn- Arg- His- Gly- Asp- Cys- Cys- Glu- Gly- Leu- Glu- Cys- Trp- Lys- Arg- Arg- Arg- Ser- Phe- Glu- Val- Cys- Val- Pro- Lys- Thr- Pro- Lys- Thr

€150,00

excl. 19% VAT

Description

(South American Tarantula, Psalmopoeus cambridgei)

M.W. 4689.4

C₂₀₀H₃₁₂N₆₂O₅₇S₆

Glu- Asp- Cys- Ile- Pro- Lys- Trp- Lys- Gly- Cys- Val- Asn- Arg- His- Gly- Asp- Cys- Cys- Glu- Gly- Leu- Glu- Cys- Trp- Lys- Arg- Arg- Arg- Ser- Phe- Glu- Val- Cys- Val- Pro- Lys- Thr- Pro- Lys- Thr

Selective Blocker for Acid-Sensitive Ion Channel, ASIC1a Psalmotoxin 1 (PcTX1), a peptide toxin composed of 40 amino acid residues was originally isolated from the venom of the West Indies tarantula Psalmopoeus cambridgei. It inhibits cation currents mediated by acid-sensing ion channels (ASIC). Psalmotoxin 1 shows high analgesic properties in mice and rat models.

Synthetic Product Trifluoracetate Form (disulfide bonds between Cys3– Cys18, Cys10– Cys23 and Cys17– Cys33 )

The purity is guaranteed to be higher than 99% by HPLC

Shipping | Storage | Stability Our product Psalmotoxin 1 (PcTX1) will be shipped at room temperature. Information about product specific storage conditions will be found on the vial. Stock solutions should be stored at -20°C. Please avoid repeated freezing and thawing by preparing aliquots.

References:

1. P. Escoubas, J.R. De Weille, A. Lecoq, S. Diochot, R. Waldmann, G. Champigny, D. Moinier, A. Ménez and M. Lazdunski, J. Biol. Chem., 275, 25116 (2000) (Original; Primary Structure & ASIC Blocking S) 2. J.K. Bubien, H.-L. Ji, G.Y. Gillespie, C.M. Fuller, J.M. Markert, T.B. Mapstone and D.J. Benos, Am. J. Physiol., 287, C1282 (2004) (Pharmacol.) 3. X. Chen, H. Kalbacher and S. Gründer, J. Gen. Physiol., 126, 71 (2005) (Pharmacol.) 4. X. Chen, H. Kalbacher and S. Gründer, J. Gen. Physio., 127, 267 (2006) (Pharmacol.)

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