Z-VAD-FMK

M.W. 467.49

C₂₂H₃₀N₃O₇F

187389-52-2

Carbobenzoxy- L-valyl- L-alanyl- β-Methyl- L-aspart-1-yl- Fluoromethane

Inhibitor for Caspases (specific pan Caspase inhibitor) Z-VAD-FMK (Z-VAD(OMe)-FMK) is a cell permeable, non seletive inhibitor for caspase-1 and caspase-3 enzymes which shows no cytotoxic effects. The benzyloxycarbonyl protected tripeptide is commonly used as inhibitor for T cell apoptosis, staunosporin induced cell death and Fas-mediate apoptosis. Our Pan Caspase inhibitor is commonly used for inflammation and apoptose studies. The chemically manufactured methylester of Z-VAD-FMK is soluble in DMSO and other organic solvents, but insoluble in water. We will ship a product specific vial instruction sheet together with the peptide.Z-VAD-FMK blocks caspases irreversible, but less selective, where as our inhibitor Ac-YVAD-CMK is specific for Caspase-1. We offer additionally the reversible Caspase-1 inhibitor Ac-YVAD-CHO. Our caspase inhibitors are manufactured in Japan by Peptide Institute Inc. and are usually available for prompt delivery ex stock Sandhausen.The related Caspase-1 substrate Ac-YVAD-AMC and Caspase-2 substrate Ac-VDVAD-AMC with the VAD Sequence is available from stock within short time .

Synthetic Product

Shipping | Storage | Stability Our product Z-VAD-FMK will be shipped at room temperature. Information about product specific storage conditions will be found on the vial. Stock solutions should be stored at -20°C. Please avoid repeated freezing and thawing by preparing aliquots.

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