Calciseptine

M.W. 7036.1

C₂₉₉H₄₆₈N₉₀O₈₇S₁₀

134710-25-1

Arg – Ile – Cys – Tyr – Ile – His – Lys – Ala – Ser – Leu – Pro – Arg – Ala – Thr – Lys – Thr – Cys – Val – Glu – Asn – Thr – Cys – Tyr – Lys – Met – Phe – Ile – Arg – Thr – Gln – Arg – Glu – Tyr – Ile – Ser – Glu – Arg – Gly – Cys – Gly – Cys – Pro – Thr – Ala – Met – Trp – Pro – Tyr – Gln – Thr – Glu – Cys – Cys – Lys – Gly -Asp – Arg – Cys – Asn – Lys

L-type Ca2+ Channel BlockerThe biological activity of Calciseptine is examined by the Division of Pharmacology, Peptide Institute, Inc. Calciseptine is a neuropeptide toxin originally isolated from the venom of the african snake Black Mamba (Dendroaspis polylepis polylepis). It is an unusually great peptide toxin with a molweight greater than 7k. Calciseptine blocks specifically L-type Ca2+ channels and shows no activity against N-type and T-type Ca2+ channels. On the other hand, Calciseptine blocks spontaneous K+-induced contraction of cardiac and smooth muscle cells.

Synthetic Product (disulfide bonds between Cys3-Cys22, Cys17-Cys39Cys41-Cys52 and Cys43-Cys58 )

The purity is guaranteed to be higher than 99% by HPLC