Liver-Expressed Antimicrobial Peptide 2 (Human)

M.W. 4581.3

C₁₉₁H₃₁₆N₆₄O₅₇S₅

Met – Thr – Pro – Phe – Trp – Arg – Gly – Val – Ser – Leu – Arg – Pro – Ile – Gly – Ala – Ser – Cys – Arg – Asp – Asp – Ser – Glu – Cys – Ile – Thr – Arg – Leu – Cys – Arg – Lys – Arg – Arg – Cys – Ser – Leu – Ser – Val – Ala – Gln – Glu

Antimicrobial Peptide in Human Blood Ultrafiltrate Liver-Expressed Antimicrobial Peptide 2 (Human) LEAP-2 [prepro LEAP-2 (38-77)] exerts antibacterial activities against Gram-positive, Gram-negative bacteria, and yeast (IC50 value was around 5 µM against Saccharomyces. cerevisiae). Interestingly, the amino-terminally truncated form, prepro-LEAP-2 (44-77), has not affected the viability of the germs tested. This 40 amino acid residue peptide, LEAP-2, has been reported to be circulating in human blood. LEAP-2 should prove to be variable in studying its role in self-defense in humans, as well as its role as an antibacterial peptide in the family of the well-established α-/β-defensin.

Synthetic Product (disulfide bonds between Cys17-Cys28 and Cys23-Cys33

The purity is guaranteed to be higher than 99% by HPLC

Shipping | Storage | Stability Our product LEAP-2 will be shipped at room temperature. Information about product specific storage conditions will be found on the vial. Stock solutions should be stored at -20°C. Please avoid repeated freezing and thawing by preparing aliquots.