ω-Agatoxin IVA

ω-Agatoxin IVA

0.1 mg
€299,00

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ω-Agatoxin IVA
  • ω-Agatoxin IVA
  • ω-Agatoxin IVA

ω-Agatoxin IVA

Produkt-ID: 4256

Lys – Lys – Lys – Cys – Ile – Ala – Lys – Asp – Tyr – Gly – Arg – Cys – Lys – Trp – Gly – Gly – Thr – Pro – Cys – Cys – Arg – Gly – Arg – Gly – Cys – Ile – Cys – Ser – Ile – Met – Gly – Thr – Asn – Cys – Glu – Cys – Lys – Pro – Arg – Leu – Ile – Met – Glu – Gly – Leu – Gly – Leu – Ala

€299,00
exkl. 19% MwSt.
Beschreibung

ω-Aga-IVA | Omega-Agatoxin IVA | omega-Aga-IVA (Funnel Web Spider, Agelenopsis aperta)

M.W. 5202.2

C217H360N68O60S10

Lys – Lys – Lys – Cys – Ile – Ala – Lys – Asp – Tyr – Gly – Arg – Cys – Lys – Trp – Gly – Gly – Thr – Pro – Cys – Cys – Arg – Gly – Arg – Gly – Cys – Ile – Cys – Ser – Ile – Met – Gly – Thr – Asn – Cys – Glu – Cys – Lys – Pro – Arg – Leu – Ile – Met – Glu – Gly – Leu – Gly – Leu – Ala

The neuropeptide toxin Omega-Agatoxin IVA is a strong P-type Ca2+ Channel selective blocker. Omega-Aga-IVA is altering the voltage-dependent gating, so that very large depolarizations are needed for channel opening. It blocks also the Q-type Ca2+-channels. These specific Ca2+-channels are essential for the release of neurotransmitters in nerve terminals of mammalians.

Synthetic Product, not from animal origin (Disulfide bonds between Cys4-Cys20, Cys12-Cys25, Cys19-Cys36 and Cys27-Cys34)

The purity is guaranteed to be higher than 99% by HPLC

Referenzen:

1. I.M. Mintz, V.J. Venema, K.M. Swiderek, T.D. Lee, B.P. Bean, and M.E. Adams, Nature, 355, 827 (1992)(Original) 2. T.J. Turner, M.E. Adams, and K. Dunlap, Science, 258, 310 (1992) (Pharmacol) 3. H. Nishio, K.Y. Kumagaye, S. Kubo, Y.-N. Chen, A. Momiyama, T. Takahashi, T. Kimura, and S. Sakakibara, Biochem. Biophys. Res. Commun, 196, 1447 (1993) (Chemical synthesis of omega-Agatoxin IVA and Biological activity)

Omega-Agatoxin IVA is distributed in the USA through Peptide Institute, Inc. Omega-Agatoxin IVA is not available in the USA via PeptaNova.

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